More than 100 million Americans commute between destinations in their automobiles (U.S. Department of Transportation, 1994). We examined perceived strain, number of negative physical symptoms, and exhaustion of employees who commute to and from work using automobiles. We gathered data through an Internet survey completed by 323 employees from across the United States who commuted to and from work daily in their automobiles. As predicted, commuters with high commute strain reported more negative physical symptoms and exhaustion than commuters with average or low levels of commute strain. Sex differences were found: women reported significantly higher levels of commute strain than did men. This study has important implications for commuters who may already be aware of their commute strain but are not aware of the negative health consequences related to elevated levels of strain.