The purpose of this study was to examine the relationship between hardiness, stress, and health-promoting behaviors among college students. Each of these concepts was measured using self-report: Personal Views Survey III-R, Health Promoting Lifestyle Profile II, Perceived Stress Scale, and College Schedule of Recent Events-Modified. Multiple regression analysis was used to predict health–promoting behaviors from a composite of predictor variables including hardiness, perceived stress, recent stressful life events, and gender. The results showed that after controlling for perceived stress, recent stressful events, and gender, hardiness was the most significant predictor of health-promoting behaviors and negatively correlated with perceived stress. The discussion focuses on the potential benefits of hardiness training for a college student population.